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C-PEPTIDE, PROINSULIN
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DeCS
Descriptor
English
:
C-Peptide
Descriptor
Spanish
:
Péptido C
Descriptor
Portuguese
:
Peptídeo C
Synonyms
English
:
C-Peptide, Proinsulin
Connecting Peptide
C Peptide
C Peptide, Proinsulin
Proinsulin C Peptide
Proinsulin C-Peptide
Tree Number:
D06.472.699.587.200.500.250
D12.644.548.586.200.500.250
Definition
English
:
The middle segment of
proinsulin
that is between the N-terminal B-chain and the C-terminal A-chain. It is a pancreatic peptide of about 31 residues, depending on the species. Upon proteolytic cleavage of
proinsulin
, equimolar
INSULIN
and
C-peptide
are released.
C-peptide
immunoassay
has been used to assess pancreatic beta cell function in diabetic
patients
with circulating
insulin antibodies
or exogenous
insulin
.
Half-life
of
C-peptide
is 30 min, almost 8 times that of
insulin.
Indexing Annotation
English
:
from
proinsulin
only: not for
peptide fragments
from other
proteins
( =
PEPTIDE FRAGMENTS
)
History Note
English
:
84(77); was see under PEPTIDES 1977-83
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
2130
Unique Identifier:
D002096
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS